There are 358 drugs known to interact with baclofen, along with 4 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 26 are major, 331 are moderate, and 1 is minor.
Baclofen may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with baclofen. Please note that only the generic name of each medication is listed below.
Currently displaying a list of 358 drugs known to interact with baclofen.
- 26 major drug interactions
- 331 moderate drug interactions
- 1 minor drug interaction
Medications known to interact with baclofen
- abobotulinumtoxinA
- acebutolol
- acetylcarbromal
- acrivastine
- aldesleukin
- alfentanil
- alfuzosin
- alprazolam
- amiloride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amyl nitrite
- apomorphine
- apraclonidine ophthalmic
- aripiprazole
- asenapine
- atenolol
- azatadine
- azelastine nasal
- azilsartan medoxomil
- benazepril
- bendroflumethiazide
- benzthiazide
- benztropine
- bepridil
- betaxolol
- biperiden
- bisoprolol
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- buspirone
- butabarbital
- butalbital
- butorphanol
- candesartan
- cannabidiol
- cannabis
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cenobamate
- cetirizine
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- citalopram
- clemastine
- clevidipine
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- codeine
- cyclizine
- cyclobenzaprine
- cyproheptadine
- dantrolene
- daridorexant
- daxibotulinumtoxinA
- deserpidine
- desflurane
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- difelikefalin
- diltiazem
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
- enalapril
- enalaprilat
- enflurane
- entacapone
- eplerenone
- eprosartan
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- etomidate
- ezogabine
- felbamate
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- flavoxate
- flibanserin
- flumazenil
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosinopril
- fosphenytoin
- fospropofol
- furosemide
- gabapentin
- gabapentin enacarbil
- ganaxolone
- guanabenz
- guanadrel
- guanethidine
- guanfacine
- halazepam
- haloperidol
- halothane
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyzine
- ifosfamide
- iloperidone
- imipramine
- incobotulinumtoxinA
- indapamide
- irbesartan
- isocarboxazid
- isoflurane
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- kava
- ketamine
- labetalol
- lamotrigine
- lasmiditan
- lemborexant
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levomethadyl acetate
- levorphanol
- lisinopril
- lithium
- lofexidine
- lorazepam
- losartan
- loxapine
- lumateperone
- lurasidone
- maprotiline
- meclizine
- melatonin
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methoxyflurane
- methsuximide
- methyclothiazide
- metoclopramide
- metolazone
- metoprolol
- metyrosine
- mibefradil
- midazolam
- minoxidil
- mirtazapine
- moexipril
- molindone
- morphine
- morphine liposomal
- nabilone
- nadolol
- nalbuphine
- nebivolol
- nefazodone
- nicardipine
- nifedipine
- nimodipine
- nisoldipine
- nitroglycerin
- nitroprusside
- nitrous oxide
- nortriptyline
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- onabotulinumtoxinA
- opicapone
- opium
- orphenadrine
- oxazepam
- oxcarbazepine
- oxycodone
- oxymorphone
- paliperidone
- paraldehyde
- paramethadione
- paroxetine
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- pimozide
- pindolol
- polythiazide
- prabotulinumtoxinA
- pramipexole
- prazosin
- pregabalin
- primidone
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
- quazepam
- quetiapine
- quinapril
- ramelteon
- ramipril
- rasagiline
- rauwolfia serpentina
- remifentanil
- remimazolam
- reserpine
- rimabotulinumtoxinB
- risperidone
- ropinirole
- rotigotine
- rufinamide
- safinamide
- scopolamine
- secobarbital
- selegiline
- sertraline
- sevoflurane
- sibutramine
- silodosin
- sodium oxybate
- sotalol
- spironolactone
- st. john’s wort
- stiripentol
- sufentanil
- suvorexant
- tamsulosin
- tapentadol
- tasimelteon
- telmisartan
- temazepam
- terazosin
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- timolol
- tizanidine
- tolcapone
- topiramate
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- valbenazine
- valerian
- valproic acid
- valsartan
- venlafaxine
- verapamil
- vigabatrin
- zaleplon
- ziconotide
- ziprasidone
- zolpidem
- zonisamide
Baclofen alcohol/food interactions
Alcohol can increase the nervous system side effects of baclofen such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with baclofen. Do not use more than the recommended dose of baclofen, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Baclofen disease interactions
There are 4 disease interactions with baclofen which include:
- renal dysfunction
- autonomic dysreflexia
- psychoses
- seizure disorders