Drug Interactions with Baclofen

Medicines that interact with baclofen may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with baclofen. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with baclofen include:

• anti-anxiety medications
• anticonvulsants
• antidepressants, such as amitriptyline, imipramine, nortriptyline, and monoamine oxidase inhibitors
• antihistamines that cause sedation, such as diphenhydramine
• opioid analgesics such as oxycodone and morphine
• other muscle relaxants such as cyclobenzaprine
• sleeping pills
• some medications used to treat mental illness, such as clozapine and thioridazine.

Alcohol may worsen the side effects of baclofen such as drowsiness and dizziness.

Note that this list is not all-inclusive and includes only common medications that may interact with baclofen. You should refer to the prescribing information for baclofen for a complete list of interactions.